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ALESSANDRA MARQUES CARDOSO
Departamento de Biomedicina

 

 


Publicações

A importância da detecção de enterobactérias produtoras de carbapenemases pelo Teste de Hodge Modificado

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A resistência aos antimicrobianos tem se tornado um problema mundial. Os carbapenens constituem terapia de escolha para tratamento de infecções causadas por bactérias multi-droga-resistentes (MDR), porém já são vários os mecanismos tilizados pelas bactérias para driblar a ação da droga, como a produção de enzimas carbapenemases. Essas enzimas podem ser detectadas através do Teste de Hodge Modificado. A importância clínica da detecção de bactérias produtoras de carbapenemases é devida à sua contribuição para o controle de infecção hospitalar, diminuindo a disseminação de micro-organismos MDR através de medidas de isolamento e fornecendo resultados que auxiliam na seleção do antimicrobiano mais adequado, prolongando a sobrevida do paciente. Palavras-chave: Enterobactérias, antimicrobianos, carbapenens, carbapenemases

Emergence of nosocomial Mycobacterium massiliense infection in Goiás, Brazil

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A cluster of surgical site infection cases after arthroscopic and laparoscopic procedures occurred between 2005 and 2007 in Goiânia, in the central region of Brazil. Nontuberculous mycobacteria (NTM) were isolated from samples (exudates from cutaneous abscesses) from 18 patients of seven private hospitals. There were no reports of post-surgical arthroscopic and laparoscopic Mycobacterial infections in Goiânia apart from this period. The 18 isolates were identified as Mycobacterium massiliense by PCR-restriction digestion of the hsp65 gene, pulsed-field gel electrophoresis (PFGE) comparisons, and rpoB partial gene sequencing. All isolates were typed as a single clone, indicating that they have the same origin, which suggests a common source of infection for all patients.

In Vitro Antimicrobial Susceptibility of Mycobacterium massiliense Recovered from Wound Samples of Patients Submitted to Arthroscopic and Laparoscopic Surgeries

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Testing of rapidly growing species of mycobacteria (RGM) against antibacterial agents has been shown to have some clinical utility. This work establishes the MICs of seven antimicrobial agents following the guidelines set forth by the Clinical and Laboratory Standards Institute (CLSI) against eighteen isolates of Mycobacterium massiliense recovered from wound samples of patients submitted to minimally invasive surgery such as arthroscopy and laparoscopy. The isolates showed susceptibility to amikacin (MIC90=4 μg/mL) and clarithromycin (MIC90<1 μg/mL) but resistance to ciprofloxacin (MIC90>16 μg/mL), doxycycline (MIC90>32 μg/mL), sulfamethoxazole (MIC90>128 μg/mL), and tobramycin (MIC90=32 μg/mL), and intermediate profile to cefoxitin (MIC90=64 μg/mL). Therefore, we suggest that the antimicrobial susceptibilities of any clinically significant RGM isolate should be performed.


 

 

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